Go with the RUGER P95, you won't be sorry. I have fired over 500 rounds in mine without a misfire or jam. In 9mm or 40 S&W for home defense. It is light in weight, light recoil, and fits the hand well.
The Colt, S&W, Baretta, Glock you just pay extra for the name.
The CZ & Taurus are just plan pieces of junk. Might work against an intruder if you threw it at them.
I have been told by many State Police Officers and other Law Enforcement Personel that a pistol is ok for home defense but the Remington 870 Shotgun with 00 Buckshot is the absolute best.