Let's make a list of things that you have tried.
Check the connections (in front of the joystick and throttle) I find that mine work their way out rather easily.
Try another USB port (I had heard that this has been able to fix some problems)
Re Install the drivers (I just figured this one out, X52 has two files that I need to execute in order to have it fully supported). One file contains the drivers, the other contains the software, that places a little icon of a joystick in your taskbar.
Let me know how things turn out. I have heard funky things about the X52, I must have gotten the only one that works well.
(Few years
and still pretty happy)
The only complaint that I have is not really the joystick's problem. When zoomed in, I notice a lot of bounce / wiggle from stick input. I mean that instead of drawing the nose left or right with rudder input, the nose moves in an egg shape movement snapping back in the direction I pulled the nose from.