The only outside system utilities that I use are O&O Defrag, and Hitman Pro. I occasionally use Driver Cleaner, or Display Driver Uninstall.
Condor, you are an intelligent individual that can research any problem your PC has and deal with them as they come along. You can also use the Windows Reset function and take Windows back to its original configuration (W10 feature). Registry cleaners are nearly all utilities that can make matters worse in a hurry.
EDIT: And Macrium Reflect (free) for cloning and backup/restore.