I play Shadowbane which is open to 100% PvP. Anyone can attack anyone and they usually do.
Griefing newbs and lowbies is a reality in it and the main reason that they quit.
After I had enough cash and items to keep me going forever in the game, I didnt care if I ever got killed. Nothing is really lost anyways. YOu just need to keep it in your head that its just a gmae and that you'll have your day in the sun too.