You guys are freaking NUTS if you are suggesting a .22 for a noob for self defense.
#1, it has LOW penetration, only the LR version has any hope of killing first shot.
#2, (someone) already touched this, the sound alone is too low, and sounds like a far off shot, so no help there.
I think someone suggested a snub .357, or a .38 special for a good all around first time revolver self defense weapon, and I have to agree.
If you are experienced with lots of loot, don't **** around, buy a damn H+K USP .40, if you really want some 'splainin to do, get a H+K MP5
But in all seriousness to AdmRose's question, I say this:
I carry a Taurus .45 in my truck, loaded with Hydrashoc ammo. Between my matresses, there is a Beretta 92F (9mm) loaded alternating with HP (hollowpoint) and standard slugs. By the night stand is a 12 guage Beretta alternating Standard Slug, Buckshot.
As for running, I have a snub .38, and it conceals great.
As for those joking about carrying, I say, grow up. Your country is not better, we can atleast defend ourselves.
Ohh, and for the knucklehead advocating not shooting to kill... get real, a wounded perpp is most likely to sue your arse into destitution as opposed to a dead perp. Remember the simple rule that the dead do not talk.