I use Firefox now because IE screws up a number of things on my home PC.
There are a few disadvantages though:
1. A hyperlink to a drive or network folder displays the contents as a webpage with the link names. In IE it just opens the folder as a real Explorer folder so that you can do whatever you want.
2. FF hoses many images made in MS Office; they look all hatched, like plaid. It also hoses a few other types of images. Unless you open pages in both browsers, you'd never know it though.
For most people, though, this stuff really doesn't matter.