I dont know how much this matters, but the gun placement for the guns are closer to the fuselage on a P40E than the P51, F6f, F4U, etc.
Having the guns closer makes for a larger "sweet spot", simple mathematics can show that. How much more effective that makes the P40E's 6/.50 cal guns is dabateable.
Something I hear a lot is "I hit that guy hard and he didnt go down", but what happens is their convergence was set to 600+ and they only were able to land one set of guns on the target. Most guys forget how perfect or near perfect things have to be for all guns to hit in the same spot and deliver enough damage to rip off plane parts, especially the .30 and .50 cal MG's. This is especially true the further out the convergence is set. Granted, enough dmg can still be had but those who put their conv all the way out to 600+ are robbing themselves of accuracy and "dmg on target" fire up close (300>) were most of the kills shots are had.