The only one that isn't good for MA play is the E-4. But, even that one is fun.
The F-4 is better for slower flying (you'll give Spitfires a real surprise!), and its not as slow as you'd expect.
The G-2 is pretty great all around, good speed and climb rate, and good turn performance as well.
The G-6 is basically like the G-2, except that the 7.9mm MG17 cowl guns are replaced with 13mm MG131's. The increase in firepower is, IMO, enough to warrant the small decrease in turn performance and climb, and the slightly larger speed deficit from the G-2.
The G-14 performs basically like the G-6, but it has an MW-50 boost system so on WEP it's pretty sweet. Great climb & speed, but it's also heavier (read: worse turn performance) than the earlier 109's.
The K-4 is the ultimate evolution, borderline-uber 109 which is extremely fast and has a great rate of climb. The only downside to the K-4 is that it can only equip the 30mm Mk108 cannon, which, though devastating is difficult to learn to use.
In pretty much all cases, when engaging contemporary aircraft the 109 is a vertical fighter.