Vertical sync should be enabled in the game. The only time you would disable it would be if you want to test your computer.
It does not hamper high performance hardware. Quite the opposite. Frame rates that float around are a problem. No matter what you believe, you cannot see more than the vertical refresh rate the monitor will deliver. In other words; When you see 300+FPS in the information display of the game, your monitor is STILL only allowing 60FPS to be displayed.
With that, you never know what frame you are actually seeing, when you have vertical sync disabled. The same frame is being repainted over and over again, then suddenly, in the middle of a frame, the image shifts causing tearing due to data over-writing the frame buffer.
There are just so many things that can go wrong with vertical sync disabled, from rubber bullets to screen tearing, to jerky motion, it is silly to consider disabling it. Your monitor cannot display anything faster than its vertical sync rate will allow.