For the MA, my guess would be that the P-40's are most difficult, although I don't fly them much, so I'm not positive about that.
I wouldn't count the Me 410 as a fighter, but if so, that one, to me, seems more difficult than even the P-40 if we are talking about fighter vs. fighter and not fighter vs. bomber.
I have flown the other candidates a fair amount (P-39D a lot, C.202, Spit I, Hurri I, Bf 109E, Bf 110C). They are all OK, in my opinion. The P-39D is not a dog -- it is reasonably fast down low, handles well at high speed, and turns reasonably well. I do better in that than I do in the P-38!
The C.202, Spit I, Hurri I, and Bf 109E are all good at turning with (except for the 109E) the main weakness being low lethality of guns, so they can still be competitive in most MA fights.