Dude, you put a 360mph, 20k payload, 35K+ ceiling, 10x.50 and 1x20mm defensive armament, 3,200 mile-range bomber in this arena for free, you may as well remove the other bombers. What's gonna catch it at alt? A 262 at 200 points? A Ta152 at 70 points? Shoot, the Japanese don't have anything to catch it at all at that height. That leaves P-38, 109, P-51, and a couple of other aircraft that have the lungs to go that high, and one teeny mistake and they are toast or miss the chance altogether.
Ever chase a B-17 or Lanc at high alt? It's hard enough. Now imagine something 70-80 mph faster.
IF and WHEN it appears, it has to be perked, and big. It WILL get through, and it WILL wreak havoc.