If you dont mind being close to suburbia, check out:
Morgan County
Berkely County
Jefferson County
The Three Counties of the Eastern Panhandle, By far the most wealthiest of West Virginia. A 90 Minute Drive from the Nations Capital. I used to live in Shepherdstown, the oldest town in West Virginia. Nice place to live, but the COL is greater than the Ohio River Valley for sure. It also has become a Yuppie Gathering Site for DC Commuters, Although its a college town too, Great Bars.
Anything West of the Blue Ridge, starts becoming very Rural, almost a different culture. When I want to go out and have a good time I have to go to Clarksburg,Bridgeport, Fairmont, Morgantown. And they pale in comparison, even to Pittsburgh. Pittsburgh PA being only 2 hours away from my location.
Where I live the closest coal mine is about 10 miles away, most Mines in Central West Virginia are closed, Coal is more prevalent to the Southern Counties, than where I live at.
The Weather is humid and Mild or Hot in the summer time, and ranges from Mild to Cold in the winter. Were a little bit to far South and in the Mountains to feel the effects of Lake Effect Snows. And Tornadoes in this area are almost non existant.
I'd say the worst part is West Virginia is the lack of culture. There is none. Its got great History, but dont expect much in the way of entertainment unless you like to gamble.
The people here are out of this world, but no different than any big city. Just depends on where your at, Eastern Panhandle, Northern Panhandle, Central and Southern West Virginians are all different.