Synthetic oils have all of their molecules smaller, and the same size. Most are ester based, and many of them cannot be used with alcohol fuels. Gasohol, 15% or less ethanol mixed with gasoline is okay, but I'd be wary of high percentages of alcohol, unless you use a synthetic made to run with alcohol. The ester in ester based synthetics is actaully an alcohol ester.
The smaller identically sized molecules is why synthetic oil lubricates well. Imagine two steel plates, with ball bearings in between them. If all of the ball bearings were exactly the same size, and small, you could put a lot more pressure on the plates holding them together and they'd still move, than if you had fewer, larger ball bearings of dissimilar sizes. That's the difference between sythetics and mineral based oils. Mineral oils have larger molecules of dissimilar sizes.
You can successfully switch an engine from mineral to synthetic oil, provided the engine is well maintained, and does not use or leak oil. I switched my Mom's Camry over to synthetic at 95K miles. It now has 200K on it with no leaks or consumption. I switched my Firebird at 12K miles when I bought it. Now at 160K miles of severe beatings, it still doesn't leak or smoke.
I have now moved from Mobil 1 to Royal Purple. Royal Purple is a better oil, and the street oil is not much if any more expensive.