Which was the "best" engine is very subjective; however I nominate the DB 603. It saw service with several LW bombers and fighters from 1943 to the end of the war. Some notable planes that used the 603 were: the Me 410, He 219, Ta 152C, Do 335. The (very) late-war DB 603N with two-stage supercharger developed 2800 hp using C3 fuel (~130 octane). With B4 (~87 octane) it developed 2000 hp.