I mean in WWII. A few high fighters above the HQ bombers, and some NOE La7s or other (short legs on the La7) low alt harrasment fighters would probably be enough to mitigate 163 defence.. I think the critical part is not letting them be seen until the 163s spawn on the runway, otherwise you get the anti-capture knee jerk reaction of mass uppers which would allow the 163s to slip thru.
P47Ns spraying lots of 50cal at 163s will almost guarantee a pretty big delay in 163s hitting the bombers. It's not such a stretch to entice fighter jocks along for a longish ride at 30k so they could have a go at rocket dweebs.