I disagree.
You may have never had it happen to you, but I have seen virus and malware attacks attempt to get to my computer.
But because XP was installed on D:/windows and it targeted C:/windows it never happened, and I was able to clean house.
Another option would be to use a Linux Boot cd once a week or so. Boot to a different OS other than windows, and use virus/malware in that distro to scan your windows side. Booting from a CD means you KNOW its not infected, and can't be messed with. Many Linux distro's come as a bootable disk, with full antivirus and malware software available. (not to mention firefox, & thunderbird) Mepis, Xandros, are just a couple of examples.
C:\Documents and Settings is a MAJOR target for almost all virus's and malware attacks.
But if it doesn't exist, or doesn't tie in to your current OS its not going to be as hard to deal with.