Cuba, I believe you can destroy the train depot where the train spawns from, again, this type of multiple target, inter-linked strat system would take alot of country cooperation, imperative timing, and some luck thrown in.
Another concern of mine is, should one destroy the train depot, I have no doubt that the train that is active would continue to resupply, so one would also have to destroy the train after they destroyed the train depot.
What would be REALLY sweet is the ability to destroy the train tracks, thus disabling the train from delivering its load, give the track a 15-30 min rebuild time.