Ive only had a few application specific issues with Vista, but nothing that wasn't easy to take care of, other than that Ive never had any problems with it.
I think the majority of bad vista experiences come from people who buy a laptop or pc that has it pre-installed and loaded to the gills with resource eating JUNK.. such as macafee.. which causes more problems than most viruses (how ironic) . bunch of manufacturer junk that dell and hp love to glob in, office.. etcetc all of them of course running on startup... so the brand new PC is already congested and running slow and of course being their first encounter with vista, naturally it gets the blame, when in reality all that is needed is a clean install to get all the CRAP off there and it would be a totally different experience.
I bought a laptop from gateway and the first start up EVER.. saw several programs failing to start, I.E. crashing.. all kinds of horror..
wiped it out, reinstalled vista.. JUST VISTA.. let it up date, threw on NOD32.. never had a problem since.