Sure. Home defense is a job for a good handgun. Home defense should never be confused with CQB, they are not at all the same.
+1.
Also, having seen the ACR/Hk416/7, etc etc etc in the field, I'd still take an Sa58 FAL or a Socom M14 ish type of rifle if having to choose a .308 short barrel weapon.
Also Shifty, you can easily take out a neighbor with a shoulder supported weapon as well. Buck and slug rounds can penetrate through structures and barriers at LEAST as well as pistol rounds. If you feel more confident with a shotgun in terms of accuracy that's good, but be sure you have a white light on it somewhere, as employing a tactical flashlight (a must in home defense situations) is very difficult with anything other than a handgun.
Here is my personal favorite historical/ish .308 rifle. Spanish Fr8. It has a very short barrel, HK style muzzle break, great little mauser action, and can be found for 150$ or less with as new bore here in Canada.
