The Mossie is a good offensive platform but a relatively poor defensive platform. When I use it I try my best to go offensive as early as possible, but the HO is reserved for situations in which I must get the numbers closer to even fast, or against Me262s or Me163s. One on one I do not go for an the HO.
Used in a BnZ fashion, the Mossie is very good if you use it aggressively to pound the victim's E out and kill them.
There are certain fighters which it will out turn, in my experience. The big ones in that category are the P-51s, P-47s and Fw190s. You can turn with a mediocre pilot in Typhoon, Tempest, La-7, late Bf109 or possibly an F4U or P-38 driver who doesn't know about the flaps.
Spitfires, C.20Xs, Hurricanes, Bf110s, F6Fs, mid and early Bf109s, F4Fs, I-16s, anything Japanese, Brewsters, Yaks and P-40s should never be turned with.