PJ Krusty actually makes that point - that they're not angles fighters but still manage well if they stick to the right of ME diagram area. He does say that the 410 flown that way should redeem itself, but the 410's specs IMO don't support that: the 410 is heavy, slow, has that unknown significant drag issue and the same top speeds as the 110, same powerloading as the 110, but has a much higher wingloading.
Have you looked at its specifications and performance figures (e.g. German wartime speed & climb trials) altogether? I stuck some of them on a wingloading & powerloading spreadsheet for comparison with the other twin engine fighters, and some of the best singles.

It's all very crude analysis/comparison (some of those figures on the right could be wrong, they're just for ballpark comparison), but already at that level the relative performances that you'd guess from the figures for all these planes do match up with reality. And there you can see the 410's powerloading is no different from the 110's, and its wingloading is easily the worst of all as soon as you add guns.. With no guns added, it's second only to the P-38 which is exceptional because it has fowler flaps. Even so, in practice you can easily feel how high the P-38's wingloading is, esp. when you leave the flaps in.
I guess one question I could ask that would put my POV to the test is - are there any planes you or DTango or anyone else knows of, with WWII wing design, that handle well or exceptionally well on the right side of an EM chart, with 47 to 50+ lbs/sqft wingloading?
On lead shots the 410 should be one of if not the best. The only possible problem there is how HTC chooses to model historical covering up of the glass panels to block muzzle flash on some of the upgunned loadouts.
The twin .50 should only be twin if the bogie stays dead 6. It gets even dodgier with AH's system: the plane goes autopilot when you jump to gunner position.