We hardly have any interceptors designed to tackle the usually 25-40k buffs in Aces high. P47? 109? 190? what else? not much.
First of all, the 335 is NOT a high altitude bomber interceptor. In fact, it's not an interceptor at all. Planes like the 152H, the P-47M, P-47N and a few more have a superior performance at very high altitudes. The 109K is way outperforming the 335 in climbing to altitude (that's one of the main features of an 'interceptor')
And many planes in Ah do quite well in the buff hunting role at 20-25k, and quite a number still fine for 25-30k. The 335A had it's best performance at 20k by the way, just like many fighters of WW2.