First off, the P-38 apparently didn't suffer nearly so much with asymmetric thrust as you might think. Considering how well Stan told me it flew on one engine, I seriously doubt he was standing on one rudder pedal and cranking the yoke around just to maintain normal level flight.
Second, this is not a regular GA engine we're talking about, this is a 1710 cubic inch 1750HP engine, it uses a lot of fuel, so running one leaves you enough power to not only still climb, but also to cruise at well over 200MPH, while reducing fuel consumption dramatically.
By the way, the yoke was actually on a control column, so the elevators were controlled just like if a stick were used, except you have two hands holding the yoke and exerting that force. The yoke itself allowed you two hands to control the "broad chord" ailerons which were way out toward the ends of a rather large wingspan. Again, this is not a GA type light aircraft, it is a large, relatively heavy, high performance aircraft. You needed a lot of muscle to control it. Every pilot who flew it that I talked to liked the yoke, feeling that it reduced the effort required to fly the plane hard, and allowed them to perform at their best with strength in reserve for a longer period of time.