It depends on how you program it. Since you can program 2 command sets you could use one for A-10C and one for BlackShark. Any key that sends a standard keycode could be programmed in any game. Any key that sends a command specific to one game, like a macro that directs your wingman, would likely not be usable in another game.
Aces High needs fewer commands then you already have available on your HOTAS.