I figured it out.
Yes, the clutch must be disengaged.  But I also found the following to be true...
Cannot use the slider for zoom in/out function.  That is what locked up everything else for some weird reason.
Also, even though I JUST bought the X52 Pro, it was packaged in 2009 (software was).  During installation, I thought I selected the option for update drivers, however, you have to MANUALLY go to Saitek's site to update the drivers.  Gives you a whole new looking screen in properties.  
If you haven't updated drivers in a while, I highly recommend doing so.
I am up and running.  Thanks again for all the help guys! 
