It has wing area twice that of 410 and 2x2250 HP where 410 has 2x1750HP. 410 max weight is 10t and P-61 is 16t.
It would certainly be a better slow speed turner but is seems that the huge wing area had its cost:
"The first P-61 engagement in the European Theater occurred on July 15 when a P-61 piloted by Lt. Herman Ernst was directed to intercept a V-1 "Buzz Bomb." Diving from above and behind to match the V-1's 350 mph (560 km/h) speed, the P-61's plastic rear cone imploded under the pressure and the attack was aborted."
"On yet another occasion, a 422nd P-61 spotted a Messerschmitt Me 410 Hornisse flying at tree top level but, as they dove on it, the "Hornet" sped away and the P-61 was unable to catch it."
I don't know what is tree top level in this case but I find it curious that a 410 flying at tree top level sped away from a plane that could catch low V1s at 350mph. Or maybe it was actually a Mossie they tried to bounce?

-C+