Latrobe,
P-51D will use aggressive BnZ attacks to drain the E out of the I-16 and then kill it when it can't dodge anymore. There is nothing the skilled I-16 pilot can do to avoid that against a skilled P-51D pilot.
I have done this to many a slow, agile, poorly accelerating aircraft and at low altitudes my preferred mount is pretty parable to the P-51D for that kind of attack. The trick is to not give your opponent the time he needs to rebuild the E he lost dodging you.
It is even more lopsided when you make the planes the P-40C vs the Spitfire Mk XVI. Zeros have more of a fighting chance than the I-16, F4F or Brewster because they build E back a lot faster and blow less dodging.