When I think I don't have the time to fly to a specific target
and back, then I chose another one. My time windows being quite short for the most part these days, so I do much more tactical or short range strat runs.
Primary goal is to fly back and land the bombers but on the big map its very hard to do it, some strats is out of range so the run is a one way mission.
I don't think I have seen any strat target so far that I could not reach and go home. Back in the day when the central strats were still retreating and I had more time, I did quite a few very long range runs. B-29 under cruise speed can fly amazing distances, but Lancs or B-17s can get a great mileag, too.