It should be noted that the 190A3 and later models were required to use C3 fuel by their BMW 801D's. The chemical synthesis of the artificial C3 fuel was relatively straightforward, but the infrastructure was simply of limited capacity.
Pre war, intention had been to transition the Luftwaffe exclusively to synthetic C3 fuel, leaving refined B4 fuel for the Heer. But production never managed to reach required levels, and so B4 continued to be used wherever possible, while C3 was for 190 units, and units operating high altitude interceptor variants of the 109, such as the G5, and G6,G14/As models.
Throughout the war, synthetic fuel had shown stability problems, but certainly nothing insurmountable. It was distributed on as-needed basis, and only in 1944 did fuel supply issues affect the Luftwaffe to any significant degree. And it's important to remember that it affected the entirety of the Luftwaffe, including units running B4 fuel.
Thought general logistics isn't my expertise, I would hazard a guess that it was in large measure related to the Allies targeting transportation hubs. Stop the fuel, stop the fighters.