It depends, 28sweep, on whether I'm flying for score, for perkies, or just for the fun of the moment. Everybodys different, but heres what works best for me...
If you fly for score, but you still want to take off from a base under attack, I would choose a fast accelerator/fast top end plane, (G-10, 190D, LA-7, etc), level out low after gear up and extend out far enough so its safe to climb out. You may want to take only %25 fuel unless you are going after bombers. Then take %50.
If you fly just for the fun of the moment, take off from a hanger with any low wing-loading plane, preferably a heavy hitter like niki, spit, Hurri, 109g-2, etc.
If the base is under heavy, heavy all-out attack you can anticipate that the red guys will not allow you to climb out unmolested. You know that with so many of them in the air, all you can do is turn, turn, turn. (You also know you it is highly likely that you will die.) For this I use the Hurri, zeke or the 109F. (I use the 109F, E or G-2 when I need perkies. The Emil is the best turning 109)
To avoid the vultures, go to the tower and watch the boomz and zooms for a minute, to time your take off when its most safe. Use the hanger if there are no bomb craters in front of it. Use flaps to get off a little sooner, and be ready to turn immediately.
Finally, give out every 6-call that you can for your buddies. If they haven't already been doing it for you, they will start. The 6 calls are key in base defenses.
G'luck. Die In Proud Defense of the Homeland