In the air during WW2? Nothing after a few seconds of flight time......
Best defense against the V-2 was intelligence, learning the location of launch sites and destroying them. To my knowledge (albeit lacking on WW2) no interception of an airborne V-2 took place. I am not aware of any attempts for that matter either, even the chance for an attempt at that.
(Even now we would have a hard time intercepting a V-2 post launch.)
Strip