Depends on your definition of BOB... I tried to suggest it lasted longer once on these forums and got blasted for it. In here they adhere strictly to the climactic battle, and that's it.
So by the general forums' standard, "no 109F" but... in that general time, in that general area, "sure, in small numbers"
I know that JG2 was doing the lion's share of spitfire mkV killing over the channel in 109F2s. I read about it and did a skin for one of their planes. They were wiping out many spits but the RAF was overwhelming them with attrition and numbers.
Personally, I don't think folks would use the MG151/15. It's barely more powerful than a single MG131. Slightly more HE, granted, but still sub-par. The ammo would also be limited.
It would be like the 1x 12.7mm option on the I-16. Nobody uses it. I have and usually run out of ammo before getting a kill (and I'm a decent shot, I suppose!)
EDIT: Anybody know what the ammo load was for the 15mm?
As a side comment: Considering it had the same engine as a 109E-4N and worse guns, I think folks might like an E-7 that had a DT, bomb rack, perhaps 90-rd ammo cans, and increased horsepower.