I've been using an X52 for about 4 years now. 2 of the buttons on the throttle are wearing out by now and activate without me pressing them sometimes. The joystick itself is getting a little stiff from all the use, but overall it still works in good condition. Almost no calibration issues, both hat-switches work fine (though I have TrackIR, so I don't use them for head movement).
I might buy another X52 when this one finally breaks. I like the feel, and have everything mapped onto it so I never have to take my hands off the controls during flight.