In the game, the only time trim becomes important,, in my opinion,, is in the chase, if I'm trying to catch someone,, or trying to run for what ever reason I will always use the trim wheels ( set up on my throttle) it does make a difference in top speed to trim it in as well as slight turns and elevation changes to use the trim wheels instead of the stick,, I found this out in a 262 in one of the racing leagues ,,,I could gain a good bit more speed flying with combat trim off using the trim wheels to fly the plane! I would bet it was the same in real life,, trim was important for top speed but flight control input during hard maneuvers would probably not be effected enough to mess with,, especially if the pilot was busy trying to fight for his life!