Not that I care for DA lake, but I can imagine, the F3 view can change dynamics of the fight quite a lot.
Only insofar as it increases SA, but most of the complaints I've seen here refer to aim. If you were to disable guns in F3 mode, that would have no effect on the SA component.
Most of the complaints about the use of F3 mode in the MA center on less than godly planes like the Sturmovik, but I don't buy that F3 mode turns Sturmies into unkillable snapshot machines. I suspect that guys like ghi would probably still continue to be successful in them with or without F3. His SA might take a hit, but he's obviously quite good at suckering people into making bad passes.