Every time I seriously sit down and think about the F-35, F-22, and B-2, all I can do is think about the Tiger, the Panther, and the Tiger II...
Consider this:
No Middle Eastern air force has any more than 250 fighters in their inventory, and most of those are 3rd generation airframes.
China has at this time 110 examples of the J-11 (indigenous copy of the SU-27), and around 50 examples of the imported SU-27 and SU-30 airframes. They also have 190 examples of the J-10.
The most numerous fighter in their inventory? Just under 300 examples of the J-7, an advanced version of the MiG-21.
Russia, if you consider them a threat (which frankly I wouldn't, they like keeping their hands clean), has around 250 examples of the MiG-29, and around 230 SU-27s.
Absolutely these numbers go way up in times of crises, but if production can happen at the rate Lockheed Martin is claiming, we would have over 300 F-35s after just one year of production. Couple that with 187 F-22s and that is quite the formidable force.