« Reply #75 on: April 03, 2020, 10:44:58 AM »
Simple nomenclature correction. R is the reproduction rate. R0 is a viruses reproduction rate with no intervention. R0 never changes unless a virus changes. Isolation lowers R not R0.
If you google for "Complexity of the Basic Reproduction Number (R ) - CDC" then there is a link to pdf document where it is said that:
Any factor having the potential to influence the contact rate, including population density (e.g., rural vs. urban), social organization (e.g., in-tegrated vs. segregated), and seasonality (e.g., wet vs. rainy season for vectorborne infections), will ultimately affect R0. Because R0 is a function of the effective contact rate, the value of R0 is a function of human social behavior and organization, as well as the innate biological characteristics of particular pathogens. More than 20 different R0 values (range 5.4–18) were reported for measles in a variety of study areas and periods (22), and a review in 2017 iden-tified feasible measles R0 values of 3.7–203.3 (23)So isolation and any other measure not creating immunity does seem to change R0.
Also:
When examining the effect of vaccination, the more appropriate metric to use is the effective reproduction number (R), which is similar to R0 but does not assume complete susceptibility of the pop-ulation and, therefore, can be estimated with populations having immune members (16,20,27).
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