« Reply #75 on: April 03, 2020, 10:44:58 AM »
									
								 
							 
							
								Simple nomenclature correction. R is the reproduction rate. R0 is a viruses reproduction rate with no intervention. R0 never changes unless a virus changes. Isolation lowers R not R0.
If you google for "Complexity of the Basic Reproduction Number (R ) - CDC" then there is a link to pdf document where it is said that:
Any  factor  having  the  potential to influence the contact rate, including population density (e.g., rural vs. urban), social organization (e.g., in-tegrated vs. segregated), and seasonality (e.g., wet vs. rainy season  for  vectorborne  infections),  will  ultimately  affect R0.  Because  R0 is a function of the effective contact rate, the value of R0 is a function of human social behavior and organization, as well as the innate biological characteristics of particular pathogens. More than 20 different R0  values  (range  5.4–18)  were  reported  for  measles  in  a  variety  of  study  areas  and  periods  (22),  and  a  review  in  2017  iden-tified feasible measles R0  values  of  3.7–203.3  (23)So isolation and any other measure not creating immunity does seem to change R0.
Also:
When  examining  the effect of vaccination, the more appropriate metric to use is the effective reproduction number (R), which is similar to R0 but does not assume complete susceptibility of the pop-ulation  and,  therefore,  can  be  estimated  with  populations  having  immune  members  (16,20,27). 
						 
						
							
							
							
								
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