From the beginning of the Pacific war and well into the war, the Japanese pilots were VERY skilled. Yet the USA won the match. How? The hardware (Speed, ROC/Zoom, High speed handling, firepower, armour and RADIO), the tactics and the teamwork. Eventually, there was the numbers too...
The P38 was one of the workhorses there, and one of the first to totally outclass the Zeke (Well, or the Hayabusha), as well as being a better attacker than anything the Japs had at the time.
In Europe and the Med, there's something different. 109F's and G's, and 190's. So, suddenly the P38 has no particular superiority in combat, but is yet able to hold it's own in a fight, - at certain altitudes, - which, mind you, is something that all the fighters share....
And it was very well multy-role. Don't see 109's doing much of the stuff the 38's did.