I probably wouldnt use a GPS...have nothing against them though, they dont seem any more dangerous or distracting as radios.
i memorize road numbers and go. have a back roads mapbook in the glove compartment as backup, and for finding more interesting routes but...roads make sense to me, i have no problem navigating as long as i've looked at the map a couple times.
when i have to go by someone elses directions, instead of mapping it out in my head, is when i have trouble. nobody seems to use normal directions and road numbers to do it.